Rooted in Longevity Science, Proven in Skin

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Targeting the Root of Cellular Dysfunction

Rooted in longevity science.  Proven in skin.

Longevity science has identified key master regulators of cell health and function that, over time, become dysregulated and contribute to cellular dysfunction, aging, and disease. By restoring their balance, we can restore our skin’s optimal function, improving both appearance and long-term skin health.

At Rapalogix, we target master regulators to address cellular dysfunction at its root, treating beyond the surface signs and symptoms of skin aging and chronic skin diseases.

Skin fibroblasts
Skin fibroblasts

Targeting the Root of Cellular Dysfunction

Longevity science has identified key master regulators of cell health and function that, over time, become dysregulated and contribute to cellular dysfunction, aging, and disease.  By restoring their balance, we can restore our skin’s optimal function, improving both appearance and long-term skin health.

At Rapalogix, we target master regulators to address cellular dysfunction at its root, treating beyond the surface signs and symptoms of skin aging and chronic skin diseases.

TORC1 Complex

mTOR—A Master Regulator of Cell Health and Longevity

mTOR—a master regulator of cell metabolism and immune function—carefully balances growth and repair activities via two complexes: TORC1 and TORC2. As we age and in many disease conditions, TORC1 becomes overactive and disrupts a cell’s ability for repair.

TORC1 inhibition has been shown to improve skin health in both aged skin and certain skin disorders, and to extend longevity overall in all species ever tested.

Healthy Fibroblast
  • Efficient energy production thanks to functional mitochondria.
  • Proper protein and molecule processing via the Golgi apparatus and ER.
  • Intact genetic material allows cells to divide and repair properly.
  • Autophagy (the cell’s recycling system) is working well helping clean up waste
Exhausted (Aged) Fibroblast
  • Damaged mitochondria = low energy.
  • Altered DNA = higher risk of errors and dysfunction.
  • Dysfunctional Golgi and ER = poor protein handling and transport.
  • Inefficient autophagy = buildup of cellular waste

Healthy Skin Begins with Healthy Cells

Whether you’re managing the signs of aging or navigating chronic conditions like rosacea or psoriasis, one truth remains: healthy skin depends on healthy cells. In their optimal state, skin cells self-repair DNA, remove internal damage through autophagy, regulate inflammation, and produce key structural proteins like collagen and elastin. When these processes break down, the result is visible aging—and in many cases, chronic skin disorders.

Healthy skin cells are capable of:
  • Self-repair (DNA repair and protein folding)
  • Autophagy and apoptosis to remove damage
  • Extracellular matrix maintenance
  • Inflammatory response regulation
  • Controlled replication and regeneration

Burden of Overstimulation of Cells

Most anti-aging and therapeutic treatments—including retinoids, lasers, peptides, and even some biologics—work by stimulating skin activity. While they may deliver short-term results, chronic overstimulation can exhaust cellular resources, impair healing, disrupt the skin barrier, and even exacerbate inflammation—particularly in sensitive or inflammatory conditions like rosacea and psoriasis.

OVERstimULAtion can cause cell damage:
  • Chronic overstimulation exhausts fibroblasts
  • Reduces regenerative skin capacity
  • Promotes cellular senescence
  • Accelerates aging-like skin changes
  • Overactive cell turnover compromises skin barrier
  • Leads to dryness, scaling, and irritation
  • Increases susceptibility to environmental irritants

The mTOR Pathway: A Cellular Tipping Point

Inside every fibroblast is mTOR, a protein complex that controls how cells grow, repair, and regenerate.But in aging skin, mTOR becomes overactive—keeping cells in a constant “on” mode.

The result: energy loss, inflammation, and cellular burnout. This cellular stress shows up as fine lines, dullness, and thinning.

mTOR is essential for regulating
  • Cell growth & proliferation  
  • Protein synthesis  
  • Nutrient sensing  
  • Cellular metabolism  
  • Autophagy (cell cleanup & recycling)  
  • Mitochondrial function  
  • Stem cell activity  
  • Inflammation response
Leverage the power of mtor:

mTOR: The Aging Accelerator

TORC1 Inhibition—Treating Beyond the Symptoms

Excessive TORC1 activity is present in multiple dermatologic disorders—rosacea, acne, atopic dermatitis, and psoriasis, among others.

TORC1 inhibition is a novel strategy that addresses multiple drivers of chronic skin disorders beyond just inflammation. This approach rebuilds skin barrier integrity, rebalances immune responses, and restores cellular function, providing a more durable solution over current treatments.

At Rapalogix, we are pioneering a new class of therapies for chronic skin conditions by selectively targeting TORC1.

Extending the Cellular Longevity Zone to Promote Youthful Skin

At the core of maintaining youthful skin is sustaining the optimal function of our skin fibroblasts. By modulating mTOR, we prolong fibroblast function and longevity, preserving youthful and resilient skin throughout our lifetime.

Rooted in longevity science and mTOR biology, Rapalogix is developing a suite of pro-longevity professional skincare products powered by our proprietary cosmetic compounds and formulations.

Healthy Fibroblast
  • Efficient energy production thanks to functional mitochondria.
  • Proper protein and molecule processing via the Golgi apparatus and ER.
  • Intact genetic material allows cells to divide and repair properly.
  • Autophagy (the cell’s recycling system) is working well helping clean up waste
Exhausted (Aged) Fibroblast
  • Damaged mitochondria = low energy.
  • Altered DNA = higher risk of errors and dysfunction.
  • Dysfunctional Golgi and ER = poor protein handling and transport.
  • Inefficient autophagy = buildup of cellular waste

Healthy Skin Begins with Healthy Cells

Whether you’re managing the signs of aging or navigating chronic conditions like rosacea or psoriasis, one truth remains: healthy skin depends on healthy cells. In their optimal state, skin cells self-repair DNA, remove internal damage through autophagy, regulate inflammation, and produce key structural proteins like collagen and elastin. When these processes break down, the result is visible aging—and in many cases, chronic skin disorders.

Healthy skin cells are capable of:
  • Self-repair (DNA repair and protein folding)
  • Autophagy and apoptosis to remove damage
  • Extracellular matrix maintenance
  • Inflammatory response regulation
  • Controlled replication and regeneration

Burden of Overstimulation of Cells

Most anti-aging and therapeutic treatments—including retinoids, lasers, peptides, and even some biologics—work by stimulating skin activity. While they may deliver short-term results, chronic overstimulation can exhaust cellular resources, impair healing, disrupt the skin barrier, and even exacerbate inflammation—particularly in sensitive or inflammatory conditions like rosacea and psoriasis.

OVERstimULAtion can cause cell damage:
  • Chronic overstimulation exhausts fibroblasts
  • Reduces regenerative skin capacity
  • Promotes cellular senescence
  • Accelerates aging-like skin changes
  • Overactive cell turnover compromises skin barrier
  • Leads to dryness, scaling, and irritation
  • Increases susceptibility to environmental irritants

Extending the Cellular Longevity Zone to Promote Youthful Skin

At the core of maintaining youthful skin is sustaining the optimal function of our skin fibroblasts. By modulating mTOR, we prolong fibroblast function and longevity, preserving youthful and resilient skin throughout our lifetime.

Rooted in longevity science and mTOR biology, Rapalogix is developing a suite of pro-longevity professional skincare products powered by our proprietary cosmetic compounds and formulations.